Stem Cell Therapy in Myocardial Infarction: Still Therapeutic Hope?
نویسندگان
چکیده
Abstract Myocardial infarction is still a therapeutic rollercoaster challenge because, despite revolutionary treatments in its management, heart failure consequence. Stem cell therapy might be turning point treating myocardial patients for regaining what lost—that is, tissue. This paper reviews the latest evidence using stem treatment of infarction, results this possible regarding cardiomyocytes, and extent to which with cells can used future management acute coronary syndromes.
منابع مشابه
[Stem cell therapy in acute myocardial infarction].
Remodeling of the left ventricle after myocardial infarction represents a major cause of infarct-related heart failure and death. Experimental data suggest that bone marrow-derived cells may contribute to the healing of myocardial infarction. The selective intracoronary transplantation of autologous, mononuclear bone marrow cells is safe and seems to be effective under clinical conditions conce...
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Myocardial infarction (MI) is caused by deprivation of oxygen and nutrients to the cardiac tissue due to blockade of coronary artery. It is a major contributor to chronic heart disease, a leading cause of mortality in the modern world. Oxygen is required to meet the constant energy demands for heart contractility, and also plays an important role in the regulation of heart function. However, re...
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Conventional therapies for myocardial infarction attenuate disease progression without contributing significantly to repair. Because of the capacity for de novo cardiogenesis, embryonic stem cells are considered a potential source for myocardial regeneration, yet limited information is available on their ultimate therapeutic value. We treated infarcted rat hearts with CGR8 embryonic stem cells ...
متن کاملResults of intracoronary stem cell therapy after acute myocardial infarction.
To assess the effect of autologous bone-marrow cell (BMC) therapy in patients with acute myocardial infarction in a rigorous double-blind, randomized, placebo-controlled trial. Patients with reperfusion >6 hours after symptom onset were randomly assigned in a 2:1 ratio to receive intracoronary BMC or placebo therapy 5 to 7 days after symptom onset. The patients were stratified according to age,...
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ژورنال
عنوان ژورنال: Romanian Journal of Cardiology
سال: 2022
ISSN: ['1220-658X', '2734-6382']
DOI: https://doi.org/10.2478/rjc-2022-0027